People vaccinated against COVID-19 may be sick…See more ​‍͏

Effectiveness in 2025–2026

  • Hospitalization Protection: Updated  vaccines reduced hospitalizations by ~55% among adults with COVID-like illness.
  • Emergency Care Visits: Effectiveness against ED/urgent care visits was ~50%, showing strong real-world impact.
  • Variant Adaptation: Omicron-adapted boosters provide superior protection compared to older monovalent doses.

Safety Profile

  • Adverse Events: Serious side effects remain rare, with most reactions mild (fever, fatigue, injection-site pain).
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